{"id":3227,"date":"2023-04-24T15:41:40","date_gmt":"2023-04-24T05:41:40","guid":{"rendered":"https:\/\/wimr.org.au\/?post_type=wimr_news&p=3227"},"modified":"2024-09-30T18:26:31","modified_gmt":"2024-09-30T08:26:31","slug":"inflammation-brake-gene-may-help-reveal-outcomes-of-kidney-disease","status":"publish","type":"news","link":"https:\/\/wimr.org.au\/news\/inflammation-brake-gene-may-help-reveal-outcomes-of-kidney-disease\/","title":{"rendered":"Inflammation \u2018brake\u2019 gene may help reveal outcomes of kidney disease"},"content":{"rendered":"

A gene that controls the cut-off switch for kidney inflammation could pave the way for more precise disease diagnostics and personalised treatments.<\/p>\n

A discovery about gene variants of an inflammation \u2018brake\u2019 brings scientists a step closer to personalised treatment for patients at risk of kidney disease and kidney failure.<\/p>\n

WIMR’s Professor Natasha Rogers co-lead the study, collaborating with researchers at the Garvan Institute of Medical Research, University of New South Wales, Sydney and Westmead Hospital, and found that common genetic variants of\u00a0TNFAIP3<\/em>, which increase inflammation in the body, can paradoxically protect the kidneys from damage in the short term.<\/p>\n

\u201cWe wanted to investigate whether inherited differences in how people regulate inflammation could lead to better or worse kidney health outcomes,\u201d says Professor Shane Grey, senior author of the paper and Head of the Transplant Immunology Lab at Garvan.<\/p>\n

\u201cWe focused on the\u00a0TNFAIP3<\/em>\u00a0gene, which produces a protein called A20 that acts as a \u2018brake\u2019 on inflammation. Common variants of\u00a0TNFAIP3<\/em>\u00a0have been linked to autoimmune disease, but their role in kidney disease was unknown. Our discovery that some genetic variants can be protective against inflammation could lead to a simple genetic test that helps predict the risk of kidney disease for patients.\u201d<\/p>\n

Unexpected protective effect of pro-inflammatory variant<\/strong>
\nAcute kidney injury \u2013 a sudden and rapid decline in kidney function that is in part caused by inflammation \u2013 is an important risk factor for progression to chronic kidney disease, a major health problem affecting approximately one in 10 Australians. Currently there are limited treatment options for acute kidney injury, and imprecise tools to predict who is most at risk of poor recovery or kidney failure.<\/p>\n

The team first investigated how different\u00a0TNFAIP3<\/em>\u00a0variants influence A20’s function, finding a series of rare variants that reduced its anti-inflammatory effect. They then tested the effects of one of the variants that promotes inflammation during kidney injury in a mouse model.
\n\"\"
\nProfessor Natasha Rogers is Deputy Director of WIMR\u2019s Centre for
\nTransplant and Renal Research, and leads the Kidney Injury Research Group and co-led the study.\u00a0 She says, \u201cDespite increasing inflammation, this rare variant surprisingly protected the kidneys from injury. We found this protection to be due to another of A20\u2019s functions: preventing cells from self-destructing.\u201d<\/p>\n

\u201cOur study indicates that these \u2018hot\u2019\u00a0TNFAIP3<\/em>\u00a0variants can alter the outcome of kidney injury, and they do so through complex effects on inflammation and cell survival.\u201d<\/p>\n

The findings are published in the journal\u00a0Kidney International<\/em><\/a>.<\/p>\n

New treatment approaches on the horizon<\/strong>
\n\u201cMore work is needed, but these findings bring us closer to being able to predict who is at risk of poor kidney recovery, and open personalised treatment approaches,\u201d says Professor Grey.<\/p>\n

The study could lead to a simple genetic test to allow doctors to determine whether an individual carries a \u2018hot\u2019 version of the inflammation control gene, giving families greater certainty about their risk factors.<\/p>\n

\u201cBy gaining a better understanding of how variants of the\u00a0TNFAIP3<\/em>\u00a0gene influence kidney health, this research brings us closer to precision diagnostics and tailored treatments for acute kidney injury,\u201d says Professor Grey. \u201cRather than a one-size-fits-all approach, we may be able to determine the best way to monitor a patient\u2019s condition based on their variant of\u00a0TNFAIP3<\/em>, and personalise interventions to boost their kidney recovery and long-term health.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

A gene that controls the cut-off switch for kidney inflammation could pave the way for more precise disease diagnostics and personalised treatments. A discovery about gene variants of an inflammation \u2018brake\u2019 brings scientists a step closer to personalised treatment for patients at risk of kidney disease and kidney failure. WIMR’s Professor Natasha Rogers co-lead the […]<\/p>\n","protected":false},"featured_media":3228,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[19],"class_list":["post-3227","news","type-news","status-publish","has-post-thumbnail","hentry","category-cat-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/wimr.org.au\/wp-json\/wp\/v2\/news\/3227","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wimr.org.au\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/wimr.org.au\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wimr.org.au\/wp-json\/wp\/v2\/media\/3228"}],"wp:attachment":[{"href":"https:\/\/wimr.org.au\/wp-json\/wp\/v2\/media?parent=3227"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wimr.org.au\/wp-json\/wp\/v2\/categories?post=3227"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}