{"id":2646,"date":"2017-09-08T17:49:37","date_gmt":"2017-09-08T07:49:37","guid":{"rendered":"https:\/\/wimr.org.au\/?post_type=wimr_news&p=2646"},"modified":"2024-09-30T18:26:36","modified_gmt":"2024-09-30T08:26:36","slug":"new-treatment-on-the-horizon-for-type-1-diabetes-sufferers","status":"publish","type":"news","link":"https:\/\/wimr.org.au\/news\/new-treatment-on-the-horizon-for-type-1-diabetes-sufferers\/","title":{"rendered":"New treatment on the horizon for type 1 diabetes sufferers"},"content":{"rendered":"

Patients suffering from type 1 diabetes may soon have access to improved approaches to treat the disease.<\/p>\n

\n

\"\"
L-R: Professor Jenny Gunton; Lead Researcher Rebecca Stokes; and Professor Wayne Hawthorne<\/figcaption><\/figure><\/figure>\n

Our team of researchers, led by Professor Jenny Gunton, discovered that pancreatic islets transplants delivered into the quadriceps muscle work just as successfully as the current clinical practice of transplanting islets into a patient\u2019s liver via the portal vein.<\/p>\n

Lead researcher Ms Rebecca Stokes said that transplants into the liver can present certain risks for the patient, so their research investigated safer and more beneficial treatment options for transplant recipients.<\/p>\n

\u201cIslets are cells in the pancreas that produce insulin,\u201d Ms Stokes explained.<\/p>\n

\u201cPancreatic islet transplantation is used as a cure for type 1 diabetes as it allows the recipient to produce and regulate insulin after their own islet cells have been destroyed by the disease.<\/p>\n

\u201cCurrently, islet transplants are infused into a patient\u2019s liver via the portal vein.\u00a0 This site is used for islet transplants due to its exposure to both nutrients and insulin in the body.<\/p>\n

\u201cHowever, islet infusion into the liver also presents certain risks for the patient, including potential complications from bleeding, blood clots and portal hypertension.<\/p>\n

\u201cThis suggests that there may be better treatment options for patients receiving islet transplants.<\/p>\n

\u201cWe investigated alternative transplantation sites for human and mouse islets in recipient mice, comparing the portal vein with quadriceps muscle and kidney, liver and spleen capsules.<\/p>\n

\u201cColleagues in Professor Wayne Hawthorne\u2019s group also tested similar sites for pig islet transplants in their companion paper.<\/p>\n

\u201cProfessor Hawthorne\u2019s research examining xenotransplantation \u2013 the process of transplanting porcine cells into humans \u2013 holds great promise for treating type 1 diabetes into the future as a solution to overcoming the shortage of donor organs available for producing human islets for transplantation.<\/p>\n

\u201cBoth studies showed that islet transplantation into the muscle site worked more successfully than transplantation into the portal vein.<\/p>\n

\u201cSkeletal muscles also hold other advantages over the portal vein as it offers easier access and greater potential for biopsies.\u00a0 A less invasive procedure would also be more appealing for patients,\u201d Ms Stokes said.<\/p>\n

\n
\n

\"Islet
Islet transplant in the quadriceps muscle<\/figcaption><\/figure><\/figure>\n<\/div>\n

Professor Gunton said these findings are encouraging and warrant further investigation.<\/p>\n

\u201cThis study is unique because comparisons of different graft sites for human islets have not previously been conducted.<\/p>\n

\u201cWe have identified a potentially new approach to treating type 1 diabetes and we now hope to progress these findings into clinical trials for humans,\u201d Professor Gunton concluded.<\/p>\n

The full research paper has been published in the Diabetologia journal:\u00a0https:\/\/link.springer.com\/article\/10.1007%2Fs00125-017-4362-8<\/a><\/p>\n

This research was published as a companion paper that examined outcomes for porcine islet cells placed in the kidney, liver and spleen.<\/p>\n

The companion paper is a promising step towards future human xenotransplantation to alleviate donor shortages of pancreatic islet cells to provide a nearly unlimited source of cells:\u00a0https:\/\/link.springer.com\/article\/10.1007\/s00125-017-4363-7<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Patients suffering from type 1 diabetes may soon have access to improved approaches to treat the disease. Our team of researchers, led by Professor Jenny Gunton, discovered that pancreatic islets transplants delivered into the quadriceps muscle work just as successfully as the current clinical practice of transplanting islets into a patient\u2019s liver via the portal […]<\/p>\n","protected":false},"featured_media":2647,"parent":0,"menu_order":0,"template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[19],"class_list":["post-2646","news","type-news","status-publish","has-post-thumbnail","hentry","category-cat-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/wimr.org.au\/wp-json\/wp\/v2\/news\/2646","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wimr.org.au\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/wimr.org.au\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wimr.org.au\/wp-json\/wp\/v2\/media\/2647"}],"wp:attachment":[{"href":"https:\/\/wimr.org.au\/wp-json\/wp\/v2\/media?parent=2646"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wimr.org.au\/wp-json\/wp\/v2\/categories?post=2646"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}